Apologies this lab experiment was performed on Thurs/Fri 4/5th May
Obtained the desired product in quantitative yields. NMR Spectra to be uploaded asap.
Reason for Experiment: Synthesised for SSP Class 2017
AEW 85 (5.00 g, 34.6 mmol, 1.00 equiv.) was dissolved in EtOH (346 mL) and then 2,4-dichlorobenzaldehyde (6.05 g, 34.6 mmol, 1.00 equiv.) was added. The brown/orange soln. was stirred for ten minutes at room temperature. A pale brown solid crashed out of the reaction mixture. The reaction was stirred for a further 2 h and then progress monitored by TLC (10% EtOAc in Hexane) - reaction complete.
Solid filtered under vacuum to give a pale brown solid 11.2 g, that was dried at the high vac to yield a pale beige/brown powder in quantitative yield. Used as crude in following SSP reactions without NMR evaluation
Hazard and Risk Assessment:
HIRAC SSP OSDD Prac 1 2016.doc
TLC at 40 min (10% EtoAc in Hexane)
AEW 273-1 (10% EtoAc in Hex).JPG