Masses and measurements:
3,4-difluorophenyl acetic acid - 0.9934g
LiAlH4 - 0.2386g
THF - 6.3mL
The 3,4-difluorophenyl acetic acid (0.9934g, 5.78mmol) was added to a RBF and was dissolved in THF (6.3mL). The reaction mixture was further stirred whilst the LiAlH4 (0.2386g, 6.29mmol) was added and the reaction mixture was stirred under reflux for 2-3 hours or until TLC analysis (1:1 ethyl acetate & petroleum ether) confirmed the completion of the reaction. Around 20mins after all reagents were added, the mixture turned a deep red and soon after turned to a pale yellow solution.
Once the reaction was complete, the reaction mixture was left to cooland quenched with 25% NaOH (10mL) and the product was seperated and extracted using 2M HCl (20mL) and ethyl acetate (20mL). Seperation of the reaction mixture gave 2 colourless solution layers. The aqueous layers were re-extracted using diethyl ether (20mL) - it was learnt in the research we underook that the alcohol product is very volatile so diethyl ether was used as it has a lower volatilty to match that of the final product. The organic layers were collected, dried using MgSO4 and filtered under vacuo. The filtrate was rotary evporated with a small amount of solvent present still. The product given was a pale yellow oily solution (0.729g, 79.85%).